SARMs & Natural Compounds Comparison Guide (2025)
For Research and Laboratory Use Only
This guide provides a research-focused comparison of SARMs and related natural compounds, highlighting their molecular properties, primary research focus, and other key characteristics. All information is for laboratory and research purposes only. None of these compounds are approved for human or animal consumption.
Quick Comparison Table
| Compound | Type | Molecular Formula | Research Focus | Common Dosage (Research) | Half-Life (Approx.) |
|---|---|---|---|---|---|
| Laxogenin | Plant-based anabolic | C27H42O5 | Muscle protein synthesis | 50-100mg/day | Unknown |
| Andarine (S-4) | SARM | C19H18F3N3O6 | Lean mass, fat loss | 25-50mg/day | 4-6 hours |
| Stenabolic (SR9009) | Rev-ErbA Ligand | C20H24ClN3O4S | Metabolic enhancement, endurance | 20-30mg/day | 4 hours |
| S-23 | SARM | C18H13ClF4N2O3 | Lean mass, male contraception research | 10-30mg/day | 12 hours |
| Turkesterone | Plant-based ecdysteroid | C27H44O8 | Muscle growth, protein synthesis | 500-1000mg/day | Unknown |
| Cardarine (GW-501516) | PPAR-delta Agonist | C21H18F3NO3S2 | Fat oxidation, endurance | 10-20mg/day | 16-24 hours |
| Ostarine (MK-2866) | SARM | C19H14F3N3O3 | Muscle wasting, bone health | 10-25mg/day | 24 hours |
| Ligandrol (LGD-4033) | SARM | C14H12F6N2O | Lean mass, strength | 5-10mg/day | 24-36 hours |
| Ibutamoren (MK-677) | Growth Hormone Secretagogue | C27H36N4O5S | GH and IGF-1 stimulation | 20-25mg/day | 24 hours |
| YK-11 | SARM / Myostatin Inhibitor | C25H34O6 | Myostatin inhibition, muscle growth | 5-10mg/day | 6-10 hours |
| Testolone (RAD-140) | SARM | C20H16ClN5O2 | Muscle growth, neuroprotection | 10-20mg/day | 16-20 hours |
What is Half-Life? The half-life of a compound refers to the time it takes for half of the substance to be eliminated from the body or broken down during research. Understanding half-life helps researchers determine optimal dosing intervals to maintain consistent levels of the compound during experimentation.
Detailed Overview
Laxogenin
A plant-based compound classified as a brassinosteroid. Research explores its potential to stimulate muscle protein synthesis without affecting hormone levels. Often studied as a natural anabolic alternative.
Andarine (S-4)
A SARM studied for its impact on lean mass and fat loss. It selectively binds to androgen receptors in muscle and bone tissue. Research has also examined its effects on strength and recovery, though with noted vision-related side effects in some studies.
Stenabolic (SR9009)
Often referred to as an exercise mimetic, SR9009 is a Rev-ErbA ligand studied for enhancing metabolism and endurance. Research suggests it may improve mitochondrial function and fat metabolism, though its short half-life requires frequent dosing in experiments.
S-23
A potent SARM investigated for its anabolic activity and potential as a male contraceptive due to its ability to suppress spermatogenesis in preclinical studies. Known for high receptor binding affinity and significant lean mass development.
Turkesterone
A naturally occurring ecdysteroid extracted from plants. Research focuses on its role in protein synthesis and muscle adaptation without influencing androgen receptors. Often studied alongside other anabolic agents for comparative effects.
Cardarine (GW-501516)
A PPAR-delta agonist, not a SARM, known for its impact on fat oxidation and endurance. Research indicates potential benefits for metabolic enhancement and increased exercise capacity through improved fatty acid metabolism.
Ostarine (MK-2866)
One of the most studied SARMs, Ostarine is researched for its potential to prevent muscle wasting and support bone health. Exhibits selective anabolic effects with minimal androgenic side effects in preclinical models.
Ligandrol (LGD-4033)
Studied for its strong anabolic effects on muscle mass and strength. Ligandrol binds selectively to androgen receptors in skeletal muscle, making it a focus of research on conditions like muscle wasting and osteoporosis.
Ibutamoren (MK-677)
A growth hormone secretagogue that stimulates the release of growth hormone and IGF-1. Research explores its impact on body composition, sleep quality, and recovery, with a long half-life allowing for once-daily dosing.
YK-11
A unique compound that acts as a SARM and myostatin inhibitor. Myostatin limits muscle growth, so YK-11 is studied for its potential to promote significant muscle hypertrophy by blocking myostatin activity.
Testolone (RAD-140)
One of the most potent SARMs under research, RAD-140 is examined for its anabolic effects on muscle tissue and potential neuroprotective benefits. It demonstrates high selectivity for androgen receptors in muscle with minimal activity in other tissues.
Important Note
All compounds listed are provided strictly for research purposes. They are not approved for human or veterinary use and should only be handled by qualified professionals in a controlled laboratory environment.
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